In 1716 he went to Seville to await passage to the Paraguay province.

By 1724 he had completed the required three years each of philosophy and theology at the Jesuit Colegio Màximo and university in Còrdoba.

Zipoli was ready to receive priest's orders in 1725, but died without them for lack of a bishop in Còrdoba to ordain him that year.

He was one of the many excellent musicians between 1650 and 1750 for work in the so-called Paraguay reduction.

His music (Oratorios, Organ Sonatas, Masses, Keyboard Pieces) was much in demand in South America.